Scientists develop new way to measure important chemical modification on RNA
A team of scientists including researchers from UCLA has developed an RNA sequencing technique that provides detailed information about a chemical modification that occurs on RNA and plays an important...
View ArticleBreakthrough in understanding how stem cells become specialized
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to...
View ArticleNeural stem cells control their own fate
To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. A research group at the University of Basel now describes for the first time a...
View ArticleHeat shock regulator controlled by on/off switch and phosphorylation
Whitehead Institute researchers have determined how the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is activated and controlled. This insight could...
View ArticleControlling gene activity in human development
Researchers at the Babraham Institute have revealed a new understanding of the molecular switches that control gene activity in human embryonic stem cells. This insight provides new avenues for...
View ArticleResearchers discover 'marvel microbes' explaining how cells became complex
In a new study, published in Nature this week, an international research group led from Uppsala University in Sweden presents the discovery of a group of microbes that provide new insights as to how...
View ArticleScientists reprogram embryonic stem cells to expand their potential cell fates
Researchers from the University of California, Berkeley, have found a way to reprogram mouse embryonic stem cells so that they exhibit developmental characteristics resembling those of fertilized eggs,...
View ArticleSwitching between freezing and flight
Andreas Lüthi and his group at the FMI have identified two types of neurons in the amygdala, each of which generates a distinct fear response – freezing or flight. In addition, these two cell types...
View ArticleScientists develop 'lab on a chip' that costs one cent to make
Researchers at the Stanford University School of Medicine have developed a way to produce a cheap and reusable diagnostic "lab on a chip" with the help of an ordinary inkjet printer.
View ArticleA comprehensive comparison of methodologies that quantify RNAs of single cells
Every cell has its own individual molecular fingerprint, which is informative for its functions and regulatory states. LMU researchers have now carried out a comprehensive comparison of methodologies...
View ArticleResearchers develop technique to track yellow fever virus replication
Researchers from Princeton University's Department of Molecular Biology have developed a new method that can precisely track the replication of yellow fever virus in individual host immune cells. The...
View ArticleHow a kernel of corn may yield answers into some cancers
Driving down a country highway in the Midwest can seem an endless ribbon flanked by green walls of corn, neatly planted in stately rows. But who would guess that a plant that feeds a planet might hold...
View ArticleTeam identifies genetic target for growing hardier plants under stress
The function of a plant's roots go well beyond simply serving as an anchor in the ground. The roots act as the plant's mouth, absorbing, storing and channeling water and nutrients essential for survival.
View Article'Pharmacoscopy' enables immunomodulatory drug discovery by analyzing immune...
The immune system consists of a great variety of cell types fulfilling diverse tasks in monitoring tissue homeostasis to protect against pathogens and to remove damaged cells. To ensure the smooth,...
View ArticlePurifying cells to treat disease
Various cell therapies involve injecting a specific cell type into a patient. These include, for example, bone marrow transplants and some types of immunotherapy that use T-cells (a white blood cell...
View ArticleResearchers use optogenetics and mathematical modelling to identify a central...
All cell types continually generate forces in the human body. An interdisciplinary cooperation of biologists and physicists including Heidelberg researcher Prof. Dr Ulrich Schwarz now succeeded in...
View ArticleNew digital method enhances understanding of changes in DNA's makeup
Scientists have developed a computational method to detect chemical changes in DNA that highlight cell diversity and may lead to a better understanding of cancer.
View ArticleWorm atlas profiles gene readouts in every cell type in the animal
The roundworm stars in the first-ever compilation of gene readouts in every kind of cell in an animal. The readouts, which were taken at a particular stage in the worm's life, reveal, for example,...
View ArticleMethod speeds up time to analyze complex microscopic images
Cryo-electron tomography permits researchers to study in detail the microscopic structures inside of cells. Researchers who typically required a week of effort to dissect the 3-D structure of a single...
View ArticleUnderstanding the language of cellular communication
A team of Caltech scientists has uncovered a molecular code that cells use to communicate with each other. This "language" is thought to be common to many types of cellular communication and has...
View ArticleRegenerating tissues with gene-targeting molecules
A synthetic DNA-targeting molecule could pave the way for tissue regeneration.
View Article3-D packaging of DNA regulates cell identity
The fundamental mechanisms governing how cells form an identity such as becoming a muscle cell or a nerve cell are not fully understood. Multiple diseases, including cancer, have been linked to cells...
View ArticleResearchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative...
View ArticleDetecting new proteins in active brains of mice
The complexity of living things is driven, in large part, by the huge diversity of cell types. Since all cells of an organism share the same genes, the diversity of cells must come from the particular...
View ArticleUncovering a reversible master switch for development
In a paper published in Genes & Development, BWH principal investigator Mitzi Kuroda, PhD, and her team identified a reversible "master switch" on most developmental genes. The team unearthed this...
View ArticleResearchers create 3-D cell arrays for more realistic experimental biological...
Paving the way for testing experimental drugs in more realistic environments, scientists at the National Institute of Standards and Technology (NIST) have discovered how to make tiny colonies of cells...
View ArticleInterrupted reprogramming converts adult cells into high yields of...
A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, potentially safer, and more cost-effective strategy for generating progenitor-like cells from...
View ArticleNew interactive technology makes rare cell types visible
Researchers from the Leiden University Medical Center (LUMC) and the Delft University of Technology (TU Delft) have presented an interactive technique in the scientific journal Nature Communications...
View ArticleResearchers look to the fruit fly to understand the human brain
The human nervous system is like a complex circuit board. When wires cross or circuits malfunction, conditions such as schizophrenia or bipolar disorder can arise.
View Article(Re)-acquiring the potential to become everything
A new study in Nature Genetics identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent-like cells in culture. Moreover, the scientists of Helmholtz Zentrum...
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